Profil Penggunaan Obat Antihipertensi di Puskesmas Surabaya.
DOI:
https://doi.org/10.31764/lf.v3i2.7679Keywords:
Antihypertensive drug, Community Health Center, Hypertension, Profile.Abstract
ABSTRAK
Hipertensi adalah penyakit kronis dengan tekanan darah sistolik dan diastolic meningkat ≥140/90 mmHg. Prevalensi pasien hipertensi meningkat di Puskesmas, sehingga perlu adanya observasi penggunaan obat antihipertensi sebagai data awal untuk melakukan monitoring penggunaan dan pengadaan obat. Penelitian ini dilakukan untuk mengetahui profil penggunaan obat antihipertensi yang meliputi nama obat, golongan dan aturan pakai obat antihipertensi. Penelitian ini merupakan penelitian observasional cross-sectional, yang dilakukan di 5 Puskesmas di Surabaya antara lain Puskesmas Benowo, Jeruk, Tambak Rejo, Gayungan, dan Ketabang. Pengumpulan data retrospektif dilakukan selama 2 bulan pada bulan Mei-Juni 2020. Berdasarkan hasil penelitian diketahui bahwa mayoritas pasien mendapatkan obat antihipertensi golongan CCB (Calcium Channel Blocker ) sebesar 82,37% dengan obat amlodipine 5 mg (49,19%) dan amlodipine 10 mg (32,95%), sedangkan untuk penggunaan obat antihipertensi kombinasi, mayoritas golongan CCB dan Diuretik Thiazid dengan nama obat Amlodipine 5 mg dan Hidroklorotiazid 25 mg (6,63%). Obat Amlodipine sebagai obat antihipertensi golongan CCB yang paling banyak digunakan dengan aturan pakai sekali sehari. Amlodipine salah satu obat antihipertensi yang toleran terhadap pasien geriatri dengan efek samping vasodilatasi yang lebih rendah dibanding obat lain dari golongan CCB dan memiliki waktu paruh yang panjang sehingga dapat diaplikasikan pada pasien kronis rawat jalan hipertensi dengan pemberian sekali sehari.
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Kata kunci : Obat antihipertensi; Puskesmas; Hipertensi; Profil.
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ABSTRACT
Hypertension is a chronic disease that is an increase in systolic and diastolic blood pressure 140/90 mmHg. The prevalence of hypertension patients is increasing at the Puskesmas, so it is necessary to observe the usage profile of antihypertensive drugs. This research is needed as initial data to monitor the use and procurement of drugs. This study aims to determine the profile of the use of antihypertensive drugs which includes the name of the drug and the rules of antihypertensive drugs. This observation is a cross-sectional study, which was conducted in 5 Public Health Center (Puskesmas) in Surabaya, including Benowo, Jeruk, Tambak Rejo, Gayungan, and Ketabang Public Health Center. Retrospective data collection was carried out for two months in May-June 2020. Based on the results of the study, it was found that the majority of patients received antihypertensive drugs from the Calcium Channel Blocker (CCB) class of 82.37% with amlodipine 5 mg (49.19%) and amlodipine 10 mg (32.95%), while for the use of combination antihypertensive drugs, the majority CCB and Thiazide Diuretics with the drug names Amlodipine 5 mg and Hydrochlorothiazide 25 mg (6.63%). Amlodipine as an antihypertensive drug of the CCB class is the most widely used in this research. Amlodipine is an antihypertensive drug that is tolerant to geriatric patients with lower vasodilation side effects than other drugs from the CCB group and has a long half-life so it can be applied to chronic hypertension outpatients and is given once a day.
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Keywords : Antihypertensive drug; Community Health Center; Hypertension; Profile.
References
Burnier, M., Egan, B. M. (2019). Adherence in Hypertension. Circulation research, 124(7), 1124–1140. https://doi.org/10.1161/CIRCRESAHA.118.313220
Egan, B. M., Bandyopadhyay, D., Shaftman, S. R., Wagner, C. S., Zhao, Y., & Yu-Isenberg, K. S. (2012). Initial monotherapy and combination therapy and hypertension control the first year. Hypertension (Dallas, Tex: 1979), 59 (6), 1124–1131.
Ernawati, I., Fandinata, S. S., Permatasari, S. N. (2020). The Effect of Leaflet on Hypertension Knowledge in Hypertensive Patients in Community Health Center in Surabaya City. Open Access Macedonian Journal of Medical Sciences, 8 (E), 558–565. https://doi.org/10.3889/oamjms.2020.5327
Fares, H., DiNicolantonio, J. J., O'Keefe, J. H., & Lavie, C. J. (2016). Amlodipine in hypertension: a first-line agent with efficacy for improving blood pressure and patient outcomes. Open heart, 3 (2), e000473. https://doi.org/10.1136/openhrt-2016-000473
Feig D. I. (2012). Hyperuricemia and hypertension. Advances in chronic kidney disease, 19 (6), 377–385. https://doi.org/10.1053/j.ackd.2012.05.009
Goodman, Gilman. (2013). Manual of Pharmacology and Therapeutics. Thirteenth Edition: New York, USA: The Mc Graw Hill
Gradman, A. H., Basile, J. N., Carter, B. L., Bakris, G. L. (2010). Combination therapy in hypertension. Journal of the American Society of Hypertension, 4 (1), 42–50. https://doi.org/10.1016/j.jash.2010.02.005
James P.A., Oparil S, Carter B.L., et al. (2014). Evidence-Based Guideline for the Management of High Blood Pressure in Adults: Report from the Panel Members Appointed to the Eighth Joint National Committee (JNC 8). JAMA, 311 (5):507–520. doi:10.1001/jama.2013.284427
Kementerian Kesehatan Republik Indonesia. (2013). Pedoman Teknis Penemuan Dan Tatalaksana Hipertensi. Jakarta: Kemenentrian Kesehatan RI
Nafirih, E., Nafisah, U., Setiyanto, R. (2021). Profil Penggunaan Obat antihipertensi di Puskesmas Jenawi Karanganyar tahun 2018. Jurnal Farmasindo; 5 (1); 47-52
Pascual J. (2000). Hypertension control in the elderly with amlodipine. Current medical research and opinion, 16 (1), 33–36. https://doi.org/10.1185/0300799009117005
Puspitasari, A. W., Azizahwati, A., Hidayat, A. R. (2017). Analysis of Potential Drugs Interaction on Antihypertension Drugs Prescription in Community Health Center of Sukmajaya District in Period of June-November 2015. Asian Journal of Pharmaceutical and Clinical Research, 10 (17), 61–65. https://doi.org/10.22159/ajpcr.2017.v10s5.23098
Ribeiro, C. D., Resqueti, V. R., Lima, Ã., Dias, F. A., Glynn, L., Fregonezi, G. A. (2015). Educational interventions for improving control of blood pressure in patients with hypertension: a systematic review protocol. BMJ open, 5 (3), e006583. https://doi.org/10.1136/bmjopen-2014-006583
Riset Kesehatan Dasar (Riskesdas). (2018). Badan Penelitian dan Pengembangan Kesehatan Kementerian RI tahun 2018. https://kesmas.kemkes.go.id/assets/upload/dir_519d41d8cd98f00/files/Hasil-riskesdas-2018_1274.pdf–diakses Oktober 2021
Triyanto E. (2014). Pelayanan Keperawatan Bagi Penderita Hipertensi Secara Terpadu. Yogyakarta: Graha Ilmu
Udayani, N. N. W., Riastini, N. W., Putra, I. M. A. S. (2018). Perbedaan Efektivitas Penggunaan Obat Amlodipin Tunggal dengan Kombinasi Amlodipin dan Lisinopril pada Pasien Hipertensi Rawat Inap di RS “X†Tabanan Tahun 2017. Jurnal Ilmiah Medicamento, 4 (2), 128-133. https://doi.org/10.36733/medicamento.v4i2.871
WHO. (2021). diakses 30 September 2021, https://www.who.int/health-topics/hypertension#tab=tab_3
Williams, B., Mancia, G., Spiering, W., Agabiti Rosei, E., Azizi, M., Burnier, M., Clement, D., Coca, A., De Simone, G., Dominiczak, A., Kahan, T., Mahfoud, F., Redon, J., Ruilope, L., Zanchetti, A., Kerins, M., Kjeldsen, S., Kreutz, R., Laurent, S., Lip, G., List of authors/Task Force members: (2018). Practice Guidelines for the management of arterial hypertension of the European Society of Hypertension and the European Society of Cardiology: ESH/ESC Task Force for the Management of Arterial Hypertension. Journal of hypertension, 36 (12), 2284–2309. https://doi.org/10.1097/HJH.0000000000001961
